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n k − is the rate of constitutive degradation of lateral signaling. Lateral signaling is mediated by complexes of LIN-12-cyto with LAG-1 transcription factor. Silencing of lateral signaling occurs due to proteosomal degradation of LIN-12-cyto [1]. The mean half-life of proteins susceptible to proteolysis has been measured to be approximately 43 minutes [2]. Therefore, the reference value of parameter n k − was set to 0.016 min.

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تاریخ انتشار 2009